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What is Pharmacogenomics

Pharmacogenomics (PGx) is the study of how your genetic makeup impacts your response to medications. PGx testing helps you know ahead of time whether a drug is likely to benefit you and be safe to take.


The rate at which your body breaks down (metabolizes) a medication can depend on your DNA. If you break down a drug faster than normal, your body gets rid of it more quickly. This leads to lower levels of the medication in your body and it might not work for you. If your body breaks down a drug slower than normal, it builds up in your body and may cause side effects. In this case, you may need less of the drug or need to avoid it all together. 

Did You Know?

1 in 4 medications approved since 2000 are affected by DNA

60% of people are prescribed at least one medication that can be affected by their DNA

1 out of 10 people take 4 or more medications that the FDA requires or recommends PGx testing for

Almost 400 FDA approved medications can be affected by DNA

Many mental health, heart, pain and cancer medications can be affected by your DNA

Adverse drug reactions are the 4th leading cause of death

Benefits of PGx

You only need to test once and it will benefit you for life

PGx can improve your health and quality of life by decreasing 

•Adverse drug reactions

•Trial and error prescribing

•Number of medications needed

•Doctor visits

•Hospitalizations and ER visits

•Disease progression

Some Common Medications Affected by DNA

Mental Health

  Celexa (citalopram)

Lexapro (escitalopram)

Paxil (paroxetine)

Zoloft (sertraline)

Effexor (venlafaxine)

Wellbutrin (bupropion)

Desyrel (trazodone)

Elavil (amitriptyline)

Pamelor (nortriptyline)

Haldol (haloperidol)

Abilify (aripiprazole)

Zyprexa (olanzapine)

Seroquel (quetiapine)

Adderall (amphetamine)

Strattera (atomoxetine)

Cardiovascular/Heart

Plavix (clopidogrel)

Zocor (simvastatin)

Crestor (rosuvastatin)

Coumadin (warfarin)

Coreg (carvedilol)

Lopressor (metoprolol)

Pain

 Celebrex (celecoxib)

Mobic (meloxicam)

Advil (ibuprofen)

Codeine based opioids (Vicodin, Percocet, etc)

Ultram (tramadol)

Soma (carisoprodol)

Cancer

Xeloda (capecitabine)

Fluorouracil/5FU

Nolvadex (tamoxifen)

Immunosuppressants

Imuran (azathioprine)

Prograf (tacrolimus)

CellCept (mycophenolic acid)

Trexall (Methotrexate)

Acid Reflux/GERD

Prilosec (omeprazole)

Protonix (pantoprazole)

Prevacid (lansoprazole)

Dexilant (dexlansoprazole)

Epilepsy/Seizure

Onfi (clobazam)

Briviact (brivaracetam)

Cerebyx (fosphenytoin) 

Dilantin (phenytoin)

Tegretol (carbamazepine)

Trileptal (oxcarbazepine)

Lamictal (lamotrigine)

Other

Zofran (ondansetron)

Vfend (voriconazole)

Zyloprim (allopurinol)

Multiple for HIV

Multiple for general anesthesia

Combination birth control

Nicotine

Sample OneOme Reports

Comprehensive Test Report (pdf)

Download

Gene Report (pdf)

Download

FDA Table of Pharmacogenetic Associations

This table includes certain established drug-gene interactions that appear in FDA-approved drug labeling as well as some additional drug-gene interactions that are not included in the FDA labeling but there is sufficient scientific evidence based on published literature. 

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References

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