Pharmacogenomics (PGx) is the study of how your genetic makeup impacts your response to medications. PGx testing helps you know ahead of time whether a drug is likely to benefit you and be safe to take.
The rate at which your body breaks down (metabolizes) a medication can depend on your DNA. If you break down a drug faster than normal, your body gets rid of it more quickly. This leads to lower levels of the medication in your body and it might not work for you. If your body breaks down a drug slower than normal, it builds up in your body and may cause side effects. In this case, you may need less of the drug or need to avoid it all together.
1 in 4 medications approved since 2000 are affected by DNA
60% of people are prescribed at least one medication that can be affected by their DNA
1 out of 10 people take 4 or more medications that the FDA requires or recommends PGx testing for
Almost 400 FDA approved medications can be affected by DNA
Many mental health, heart, pain and cancer medications can be affected by your DNA
Adverse drug reactions are the 4th leading cause of death
PGx can improve your health and quality of life by decreasing
•Adverse drug reactions
•Trial and error prescribing
•Number of medications needed
•Doctor visits
•Hospitalizations and ER visits
•Disease progression
Celexa (citalopram)
Lexapro (escitalopram)
Paxil (paroxetine)
Zoloft (sertraline)
Effexor (venlafaxine)
Wellbutrin (bupropion)
Desyrel (trazodone)
Elavil (amitriptyline)
Pamelor (nortriptyline)
Haldol (haloperidol)
Abilify (aripiprazole)
Zyprexa (olanzapine)
Seroquel (quetiapine)
Adderall (amphetamine)
Strattera (atomoxetine)
Plavix (clopidogrel)
Zocor (simvastatin)
Crestor (rosuvastatin)
Coumadin (warfarin)
Coreg (carvedilol)
Lopressor (metoprolol)
Celebrex (celecoxib)
Mobic (meloxicam)
Advil (ibuprofen)
Codeine based opioids (Vicodin, Percocet, etc)
Ultram (tramadol)
Soma (carisoprodol)
Xeloda (capecitabine)
Fluorouracil/5FU
Nolvadex (tamoxifen)
Imuran (azathioprine)
Prograf (tacrolimus)
CellCept (mycophenolic acid)
Trexall (Methotrexate)
Prilosec (omeprazole)
Protonix (pantoprazole)
Prevacid (lansoprazole)
Dexilant (dexlansoprazole)
Onfi (clobazam)
Briviact (brivaracetam)
Cerebyx (fosphenytoin)
Dilantin (phenytoin)
Tegretol (carbamazepine)
Trileptal (oxcarbazepine)
Lamictal (lamotrigine)
Zofran (ondansetron)
Vfend (voriconazole)
Zyloprim (allopurinol)
Multiple for HIV
Multiple for general anesthesia
Combination birth control
Nicotine
This table includes certain established drug-gene interactions that appear in FDA-approved drug labeling as well as some additional drug-gene interactions that are not included in the FDA labeling but there is sufficient scientific evidence based on published literature.
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